Villa are set to confirm the controversial appointment of former Birmingham boss McLeish after successful talks with the 52-year-old this week.
McLeish only quit at St Andrew's on Sunday and the prospect of him moving across the city has enraged Villa supporters.
New man: Alex McLeish (right) will be appointed Aston Villa manager, taking over from Gerard Houllier (back)
But Ferguson, often regarded as a mentor for McLeish having given him his break as a player at Aberdeen, is convinced his fellow Scot will prove doubters wrong.
The 70-year-old said: 'At the end of the day what will count is this - can he do the job for Villa?
'It doesn't matter whether there are 50 against him, 500 against him or five against him because the experience and the ability he has got, believe me, he will prove that he can do the job.
'I've known him for a long time and I know his abilities. I know how conscientious he is.
'I know the determination and work ethic he's always had to make sure he does the job right.'
Safe hands: Sir Alex Ferguson (right) believes McLeish (left) will be up to the job at Aston Villa
Fans' ire culminated with a protest at Villa Park on Wednesday evening but that depth of ill-feeling has not deterred club owner Randy Lerner from pursuing McLeish.
Villa were also not put off by a war of words with Birmingham, who claimed McLeish was tapped up and threatened to take out an injunction to block his appointment.
That was not carried out and nor was a threat to report Villa to the Premier League.
Blues, however, did demand ?5.4million in compensation to cover the final two years of McLeish's contract.
There were reports last night that a compromise figure of ?2m had been agreed but there was no confirmation from either club.
Yet with a contract with McLeish understood to have been finalised, it is thought only legal issues concerning Birmingham are preventing the appointment from being officially confirmed.
Uproar: Aston Villa supporters protest against McLeish on the steps outside Villa Park
McLeish began his managerial career with Motherwell and Hibernian before winning two league titles with Rangers and then taking over the Scotland national side.
He won the Carling Cup with Birmingham last season only for the campaign to end in the disappointment of relegation from the Barclays Premier League.
He will become Villa's third full-time manager in nine months and succeed Gerard Houllier, who left the club after a health scare.
Ferguson added: 'I have known Alex since he was 18 years of age when he went to Aberdeen.
'He was always intelligent, he was always inquisitive in his nature, he was always asking questions, and these to me are essential ingredients for being a successful manager.'
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?Explore more:People: Alex Ferguson, Gerard Houllier, Alex McLeish Places: Birmingham, Aberdeen, Scotland
Source: Daily Mail
Source: Daily Mail