Agbonlahor was in fine form on his England debut against Germany in Berlin on Wednesday and received plenty of plaudits.
Now he will be aiming to destroy a top four club for the second week in succession after a great goal against Arsenal sealed a 2-0 win for Villa.
Ironically, the last time the Claret and Blue triumphed against Sir Alex Ferguson's men in the league was in 1995 when the Scot put a side out made up of, as Alan Hansen labelled them, "kids".
David Beckham, Paul Scholes and the Neville brothers all played their part but goals from Ian Taylor, Mark Draper and Dwight Yorke gave Villa victory in the Midlands.
This time it will be Villa who will be looking to their younger players, with 22 year old Agbonlahor spearheading the attack.
Question
Ashley Young, 23, will also be required to play a key part if Villa are to halt United's winning run at Villa Park.
Older citizens Martin Laursen and John Carew will have to use all their experience if Villa are to have a chance of beating Wayne Rooney and Co.
Carew should return to the starting line up as Villa look to press their illustrious opponents.
However, that would raise the question of who should be left out as the whole team put on a superb show at the Emirates last Saturday.
United could be without Rio Ferdinand and Wayne Rooney, who both missed England's fine win in midweek. But, both are expected to be fit.
They are definitely missing the injured Dimitar Berbatov and Wes Brown so Carlos Tevez and Gary Neville are expected to start.
Whoever Ferguson puts out will test Villa but Agbonlahor and Co will be hoping that just for once they can defy the odds and beat their nemesis.